INTERNATIONAL SOCIETY FOR IMMUNOLOGY OF
REPRODUCTION
(ISIR)
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The 16th ISIR meeting will be held in 2026. |
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This site is for announcing meetings, jobs, and funding opportunities. If you have any news to share, please contact
Sandra Blois, Secretary-General
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ESRI Congress - 2022, Paris |
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XIV Congress of the International Society for Immunology of Reproduction (ISIR) hosted by JAPAN Society for Immunology of Reproduction will be held at Nara, Japan in the year 2019. Nara is an old capital in Japan, and there are many temples and shrines. It has very easy access from Kansai – Osaka airport.
For further information please contact Prof. Shigeru Saito Professor and Chairman Department of Obstetrics & Gynaecology Graduate School of Medicine and Pharmaceutical Science and Research Faculty of Medicine University of Toyama 2630 Sugitani, Toyama 930-0194 Japan Tel +81 76 434 7355 Fax +81 76 434 5036 E-mail: s30saito@med.u-toyama.ac.jp
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Editors; Gérard Chaouat, Olivier Sandra and Nathalie Ledee Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conceptus) and a friend (immune cells and molecules are also necessary for successful pregnancy). Leukemia Inhibitory Factor (LIF) when absent, prevents embryo implantation in rodents. From fecundation to parturition, immunity acts as a Janus, required but potentially dangerous. However, the complexity and the diversity of immunity in pregnancy deter many from entering the field. This book will try to give a complete overview of immunity from gametes till parturition, in brief, but with complete chapters and subsections, each written by leading specialists in the field. The importance of the topic relies not only on “the riddle of the fetal allograft”, which is per se fascinating, but on its consequences, linked to the development of IVF and in general, Assisted Reproductive Technologies (ART) / Medicine. Since the discovery that there would not be (mammalian) life without LIF, it has become clear that in general, Immune Molecules, and most specifically a transient post mating inflammatory reaction are required for successful implantation. Disruptions of this process can lead to implantation failure / sterility. In later stages of pregnancy immunological cells, mostly of the innate immune system, control formation of local spiral arteries. Finally, a state of tolerance establishes itself, whose “break” leads to immune abortion. Also the vascular bed is further transformed and enlarged, till delivery, and here again “immunological cytokines” do play a major role and can eventually cause immune mediated abortion. Failure of, not just, the cytokine and cell recognition mediated dialogue, but also of the pre and peri-implantation “preparation of the uterus”, as stated, leads to sterility, early pregnancy loss and recurrent abortions. There is also an increasingly stronger series of argument to implicate immunology in pre-eclampsia. Further still, immunology is also implicated in the control of local infection, mother to child transmission of pathogens (notably, but not limited to, HIV). Finally, pregnancy is the only known physiological allorecognition phenomenon where the once named “suppressor T cells,” now re-emerged as “regulatory T cells”, play a cardinal role. This E-book provides a complete compendium of gynecological immunology, spanning from fecundation to delivery. Topics also include the role of various cell types (such as T regs and NK cells) in implantation and uterine changes as well as the genetic regulation of immunological processes. As such it will be of interest not only to mainstream and reproductive immunologists, but more importantly, clinicians in obstetrics and gynecology. Contents 1. Innate and Adaptive Immunity in the Human Female Reproductive Tract: Bridging the Menstrual Cycle with Pregnancy Charles R. Wira, Mickey V. Patel, Mimi Ghosh and Zheng Shen, Marta Rodríguez-García 2. Immunity and Sperm: Auto- and Iso Immunization Koji Koyama 3. Contraceptive Vaccines: Past, Present and Future Satish K. Gupta 4. Immune Markers of Oocyte and Embryo Quality Nathalie Lédée 5. MHC Antigens Expression/ Function at the Embryonic Interface Part A: Major Histocompatibility Complex Class I Unique Expression in Human Trophoblast: Facts, Questions and Controversies Philippe Le Bouteiller Part B: Expression of MHC-I Proteins by the Placenta of Domestic and Laboratory Animals Heloisa M. Rutigliano, Aaron J. Thomas and Christopher J. Davies 6. Immunology of Implantation, Implantation Failure and Pregnancy Part A: Regulators of Early Invasion of Trophoblast Cells Pankash Shuman and Satish K. Gupta Part B: Dendritic Cells: New Insights in Reproduction Sandra M. Blois, Petra C. Arck and Gabriel Barrientos Part C: A Summary of Cytokine Networks and Embryo: A Short Overview Gerard Chaouat Part D: Human Implantation Nathalie Lédée and Mona Rahmati Part E: Interleukin-10: A Vascular and Anti-Inflammatory Cytokine Connecting the Pieces of the Pregnancy Puzzle Satyan Kalkunte, Tania Nevers, Eliana Lippe and Surendra Sharma Part F: Functional Duality of Mouse Uterine Natural Killer Cell in Pregnancy Patricia D.A. Lima, Valdemar A. Paffaro Jr. and Aureo T. Yamada Part G: Human Uterine Natural Killer Cells. Friend or Foes of Pregnancy Outcomes Eliana M O Lippe, Aureo T Yamada and Surendra Sharma Part H: Factors Elevated during Sexual Intercourse Act to Assist Pregnancy Outcome Mukesh K. Jaiswal, Timothy M. Millers, Alice Gilman-Sachs and Kenneth D. Beaman Part I: Substances Secreted by the Preimplantation Human Embryo Georgi Georgiev, Jana Pastuschek, Stefan Neubeck and Udo R. Markert Part J: Placental Interferons, Implantation and Pregnancy Fuller W. Bazer Part K: Pathophysiology of the Complement System at Feto-Maternal Interface Roberta Bulla, Chiara Agostinis and Francesco Tedesco Part L: Toll-like Receptors and Nod-Like Receptors in Gestational Tissues Vikki M. Abrahams 7. Tolerance to the Fetal Allograft Part A: Is the Fetus an Allograft and is it Object of Immunological Tolerance? Gérard Chaouat Part B: Immunoregulation at the Interface by Placental Suppressor Factors Gérard Chaouat Part C: Decidual Transforming Growth Factors and Tolerance Signalling Molecules David A. Clark and Reginald M. Gorczynski Part D: Role of Regulatory T Cells in Human Reproduction Leonardo Fainboim Part E: the Role of Cytotoxic Natural Killer (NK) Cells and Regulatory NK Cells in Pregnancy Shigeru Saito, Tomoko Shima, Akitoshi Nakashima and Yi Lin Part F: Pathways for Activating Implantation Tolerance in Early Pregnancy Sarah A. Robertson, David J. Sharkey, John E. Schjenken, Alison S. Care and Lachlan M. Moldenhauer 8. Immuno Endocrine Interactions: An Example Progestagen Treatment for Threatened and Recurrent Abortion; Molecular Mechanisms Julia Szekeres-Bartho, Melinda Halasz, Beata Polgar and Agnes Bogdan 9. The Maternal Inflammatory Response to Pregnancy Jennifer H. Southcombe and Ian L. Sargent 10. Are there Abortions of Immunological Origin? Part A: Animal Models of Spontaneous Immunological Abortions Gérard Chaouat Part B: Immunology and Recurrent Pregnancy Loss. Epidemiological Aspects in Humans Ole B. Christiansen Part C: Immune Treatments Recent Developments Edward E. Winger and Jane L. Reed Part D: Debates on Immunotherapy for Recurrent Pregnancy Failure David A. Clark Part E: Debates on Immunotherapy for Recurrent Pregnancy Failure Gérard Chaouat 11. Impact of the Immune System on Trophoblast Invasion and Uteroplacental Blood Flow Raj Raghupathy 12. Epidemiology and Immunology of Preeclampsia Part A: Preeclampsia, Plague of Human Reproduction. The Role of Paternity and Immunological Implications Pierre-Yves Robillard and Gustaaf Dekker Part B: Animal Models for a Cure for Preeclampsia Guillermina Girardi 13. Autoimmunity in Association with Pregnancy Nobert Gleicher 14. The Control of HIV-1 In Utero Transmission at the Materno-Foetal Interface by Immunological Determinants Héloïse Quillay, Romain Marlin, Marion Duriez, Marie-Thérèse Nugeyre and Elisabeth Menu Annex 1: Immunology for Assisted Reproductive Medicine Practitioners: A Comprehensive Overview Ae-Ra Han, Alice Gilman-Sachs, Joon W. Kim and Joanne Kwak-
Kim.
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